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Updated: Jul 4, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from
Wen-Chuan Kuo1, Ming-Wei Hsiung, Jeou-Jong Shyu
1Institute of Electro-optical Science and Technology, National Taiwan Normal University, 88, Sec. 4, Ting-Chou Road, Taipei 116, Taiwan. kwchuan@ntnu.edu.tw
Abstract:
In this research, we assessed arterial characteristics in human atherosclerosis by determining both scattering and birefringence properties of vessel tissue from polarization-sensitive optical coherence tomography (PS-OCT) images. We demonstrated that optical characteristics including scattering coefficient (mu(s)), effective anisotropy factor (g(eff)), birefringence coefficient (Delta n), and fast-axis angle (beta) of normal and different kinds of atherosclerotic lesions in human vessels can be quantitatively described. Based on our findings, a quantitative PS-OCT image criterion for plaque characterization was constructed.
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