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Updated: Jul 4, 2026
11:39
Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos
Published on: April 29, 2016
Cell biology of embryonic migration
Satoshi Kurosaka1, Anna Kashina
1Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Birth Defects Research. Part C, Embryo Today : Reviews
|June 12, 2008
Summary
Cell migration is a fundamental process in development and disease, involving conserved molecular mechanisms. This review integrates intracellular and extracellular factors to understand cell movement coordination during development.
Area of Science:
- Cell and Developmental Biology
- Molecular and Cellular Biology
Background:
- Cell migration is crucial for development, wound healing, immune response, and cancer metastasis.
- Conserved molecular mechanisms, involving cytoskeleton-based machines, drive cell migration across species.
- Coordination of cell migration involves both intracellular and extracellular regulatory aspects.
Purpose of the Study:
- To review and integrate current knowledge on cell migration mechanisms during development.
- To bridge the gap between studies focusing on intracellular mechanisms and extracellular regulation of cell migration.
- To provide a comprehensive overview of emerging data in cell and developmental biology related to cell migration.
Main Methods:
- Literature review and synthesis of existing data.
- Integration of findings from cell biology and developmental biology research.
- Analysis of conserved molecular and cellular mechanisms of cell migration.
Main Results:
- Cell migration relies on evolutionarily conserved, cytoskeleton-based molecular machines.
- Intracellular and extracellular factors intricately coordinate cell migration.
- Perturbations in these mechanisms lead to significant developmental defects.
Conclusions:
- Understanding cell migration requires integrating intracellular processes with extracellular context.
- Further research integrating these aspects will illuminate developmental processes and diseases.
- This review highlights the complexity and conserved nature of cell migration in development.
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