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Updated: Jul 4, 2026

Laminectomy and Spinal Cord Window Implantation in the Mouse
Published on: October 23, 2019
[Clinical use of remifentanil in neuroanesthesia]
Kiyotaka Sato1, Hideyuki Kamii, Masato Kato
1Department of Neuroanesthesia, Kohnan Hospital, Sendai.
Background:
Early detection of complications after craniotomies are important and remifentanil may be beneficial for that purpose because of the short and constant context-sensitive half time. To examine the efficacy of remifentanil in neuroanesthesia, we investigated hemodynamic properities and recovery from anesthsia in craniotomies.
Methods:
Fifty patients undergoing scheduled neurosurgical procedures were included. Anesthesia was induced and maintained with propofol, vecuronium and fentanyl (group C, 25 cases) or remifentanil (group R, 25 cases).
Results:
There were no diffirences between the groups in age, sex distribution, procedure, duration of anesthesia, and amount of bleeding. Total dose of propofol was lower in group R (3.4+/-1.0 mg x kg(-1) x hr(-1)) than group C (4.9+/-0.8) (P<0.001). Incidence of hemodynamic changes at tracheal intubation was higher in group C (P<0.01) and bradycardia (HR<45) was more frequent in group R (P<0.001). Recovery time was shorter in group R (12.7+/-4.7 min) than that in group C (20.7+/-7.3) (P<0.001).
Conclusions:
Remifentanil is suitable for neuroanesthesia because of the hemodynamic stability and quick recovery from anesthesia.
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