Inflammatory and allergic responses to airborne office dust in five human provocation experiments

Five studies on the effects of dust have been published from The Department of Environmental and Occupational Medicine, the University of Aarhus, Denmark. These five studies support that exposures to normal office dust for up to 5 h at concentration ranges occasionally seen in non-occupational indoor environments may cause health effects which can be measured both objectively and subjectively in healthy subjects and subjects with different types of hypersensitivity. In these five studies, the lowest observed effect level was indicated to be 75 microg/m3 (total suspended particulates). However, dust from different buildings may have different toxicity and some of the five studies had higher No Observed Effect Level (NOEL) than this value. The studies give strong evidence that dust exposures cause decreased tear film stability or break-up time and increased number of eosinophil cells in nasal lavages. There is also strong evidence that general well-being decrease during exposures. This is also reflected in increasing general irritation in eyes, nose, and throat. The combined findings support the theory that the subjects' responses to indoor dust exposures are caused by sensory perceptions, weak allergic, or weak inflammatory responses at or in the exposed tissues. More than one biological mechanism may be involved at the same time or subsequently. No signs of effects in non-exposed organs or tissues were seen, not even in sensitive persons.

The studies indicate that dust exposures indoors may explain many reported symptoms and health effects and underlines the importance of source reduction.