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An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

[Mechanisms underlying thyroid hormone response gene regulation during amphibian development]

Emmanuelle Havis1, Patrice Bilesimo, Barbara A Demeneix

  • 1UMR5166 CNRS, USM-501 Muséum National d'Histoire Naturelle, Département Régulation Développement et Diversité Moléculaire, CP32, 7 rue Cuvier, 75231 Paris Cedex 05, France.

Journal De La Societe De Biologie
|June 13, 2008
PubMed
Summary

Thyroid hormones (TH) orchestrate amphibian metamorphosis by regulating gene expression through thyroid hormone receptors (TR). Unliganded TR repress and liganded TR activate transcription, with gene-specific responses explaining TH

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