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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jul 4, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Mesenchymal cells for skeletal tissue engineering.

Bethany J Slater1, Matthew D Kwan, Deepak M Gupta

  • 1Stanford University School of Medicine, Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, 257 Campus Drive, Stanford, CA 94305-5148, USA.

Expert Opinion on Biological Therapy
|June 14, 2008
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells show promise for skeletal tissue engineering and bone regeneration. Further research into molecular signaling is key for future clinical applications in treating skeletal defects.

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Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
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Last Updated: Jul 4, 2026

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Skeletal defects pose a significant socioeconomic burden.
  • Current methods for reconstructing bone deficits are inadequate.
  • There is a need for innovative approaches in skeletal tissue engineering.

Purpose of the Study:

  • To review the application of mesenchymal stem cells (MSCs) in skeletal tissue engineering.
  • To explore the optimization of MSC-based techniques for bone regeneration.
  • To discuss the tropic effects and future directions of MSCs in skeletal applications.

Main Methods:

  • Focused on mesenchymal cell applications in skeletal regeneration.
  • Investigated optimization strategies for MSC-based therapies.
  • Examined the role of multipotent mesenchymal cells and their tropic effects.

Main Results:

  • Mesenchymal stem cells, particularly adipose-derived stromal cells, are being investigated for bone regeneration.
  • Understanding the mechanisms of osteogenic differentiation is crucial.
  • The acceleration of bone regeneration processes is a key area of interest.

Conclusions:

  • Cell-based modalities, including MSCs, are under investigation for skeletal defects.
  • Further understanding of molecular signaling in osteogenic differentiation is required.
  • Maintaining progenitor cell pluripotency is essential for successful clinical translation.