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Related Experiment Video

Updated: Jul 4, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Pituitary blastoma.

Bernd W Scheithauer1, Kalman Kovacs, Eva Horvath

  • 1Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA. scheithauer.bernd@mayo.edu

Acta Neuropathologica
|June 14, 2008
PubMed
Summary
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This study reports a rare pituitary blastoma in a 13-month-old, presenting with Cushing disease. The tumor contained multiple pituitary cell types and primitive Rathke-type epithelium, suggesting developmental origins.

Area of Science:

  • Endocrinology
  • Pediatric Pathology
  • Neuro-oncology

Background:

  • Cushing disease and diabetes insipidus in infants are rare and often associated with pituitary tumors.
  • Pituitary blastomas are exceptionally rare tumors, hypothesized to arise from developmental remnants of the anterior pituitary gland.

Observation:

  • A 13-month-old Korean female presented with symptoms of Cushing disease and diabetes insipidus.
  • MRI revealed a large, cystic, sellar/suprasellar mass with contrast enhancement.
  • Histopathological examination of the resected tumor showed a complex mixture of endocrine cells and primitive Rathke-type epithelium.

Findings:

  • The tumor exhibited immunoreactivity for adrenocorticotropin (ACTH), growth hormone (GH), and luteinizing hormone (LH), along with transcription factors like Neuro-D1 and Pit-1.

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Last Updated: Jul 4, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Published on: January 17, 2018

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Published on: July 5, 2021

  • Ultrastructural analysis revealed features resembling the fetal pituitary at 10-12 weeks gestation.
  • The presence of diverse cell types, lobular arrangement, and primitive epithelium supported the diagnosis of pituitary blastoma.

    • Implications:

    • This case expands the understanding of pituitary blastomas and their diverse cellular components.
    • The findings suggest a developmental origin for these rare tumors, offering insights into pituitary embryogenesis.
    • Accurate diagnosis is crucial for appropriate management and understanding the clinical course of pituitary blastomas in pediatric patients.