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Prolactinomas: diagnosis and treatment
Farshad Nassiri1, Michael D Cusimano1, Bernd W Scheithauer2
1a Department of Surgery, Division of Neurosurgery, St Michael's Hospital, University of Toronto, ON, Canada.
Abstract:
Pituitary lactotrophs secrete prolactin. This process is enhanced by estrogen and inhibited by dopamine. Prolactinomas are benign neoplasms that rarely increase in size and are classified according to size as microadenomas (<10 mm diameter) or macroadenomas (>10 mm diameter). The clinical features of prolactinomas most commonly result from prolactin's effect on the gonads and breast in women and from mass effect in men. This review details the clinical features and management of patients with prolactinomas.
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