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Searching the MINT database for protein interaction information.

Gianni Cesareni1, Andrew Chatr-Aryamontri1, Luana Licata1

  • 1University of Rome Tor Vergata, Rome, Italy.

Current Protocols in Bioinformatics
|June 14, 2008
PubMed
Summary
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The Molecular Interactions Database (MINT) is a key resource for protein interaction data. It offers protocols for accessing and visualizing nearly 30,000 proteins and 100,000 interactions from diverse organisms.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Molecular Biology

Background:

  • Protein interactions are fundamental to cellular processes.
  • Comprehensive databases are crucial for understanding complex biological networks.
  • The Molecular Interactions Database (MINT) serves as a centralized repository for this data.

Purpose of the Study:

  • To describe the Molecular Interactions Database (MINT).
  • To provide protocols for accessing and utilizing MINT data.
  • To highlight the scope and utility of MINT for researchers.

Main Methods:

  • Expert curators extract protein interaction data from scientific literature.
  • Information is stored in a relational database format.
  • Protocols for internet-based searching and visualization using MINT Viewer are provided.

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Main Results:

  • As of April 2008, MINT contains data on nearly 29,000 proteins.
  • The database includes over 100,000 protein interactions.
  • Data spans more than 30 model organisms.

Conclusions:

  • MINT is a valuable resource for protein interaction information.
  • The database facilitates research in molecular biology and systems biology.
  • Protocols enable efficient access and analysis of interaction data.