Related Experiment Video
Updated: Jan 23, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Cellular basis of drug-induced torsades de pointes
1Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. dan.roden@vanderbilt.edu
Abstract:
Striking QT prolongation and the morphologically distinctive ventricular tachycardia torsades de pointes can occur in up to 5% of patients treated with certain antiarrhythmic drugs. This adverse drug reaction also occurs, albeit far less frequently, during therapy with a range of drugs not used for cardiovascular indications; examples include certain antibiotics, antipsychotics and antihistamines. The common mechanism for drug-induced torsades de pointes is inhibition of a specific repolarizing potassium current, I(Kr). The key question facing clinicians, regulators and those who develop drugs is why torsades de pointes only occurs in some patients exposed to I(Kr) block. This paper reviews the clinical, cellular, molecular and genetic features of the arrhythmia that may provide an answer to this question and proposes future studies in this area.
More Related Videos
08:31Kinematic Analysis of Cell Division and Expansion: Quantifying the Cellular Basis of Growth and Sampling Developmental Zones in Zea mays Leaves
Published on: December 2, 2016
18:57Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Related Concept Videos
Introduction to Cellular Respiration
ATP stores energy in chemical bonds that can be quickly released when needed. Cells produce energy in the form of ATP through the process of cellular respiration. Although much of the energy from cellular respiration is released as heat, some of it is used to make ATP.
During cellular respiration, several...
Bioequivalence of Drugs: Drugs with Multiple Indications
Pharmacokinetics: Drug–Drug Interactions
Cellular Respiration
Cellular Membranes and Drug Transport
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Cellular Differentiation
A zygote is a...