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Toxicological screening of drugs by microbore high-performance liquid chromatography with photodiode-array detection
A Turcant1, A Premel-Cabic, A Cailleux
1Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.
Clinical Chemistry
|July 1, 1991
Abstract:
We use ultraviolet data, acquired with a photodiode-array detector coupled to a reversed-phase liquid-chromatographic system, to identify unknown drugs in plasma samples of acutely poisoned patients. Both retention time and spectra of the peaks obtained with a microbore Hypersil ODS column under gradient elution are compared with a library of approximately 350 compounds. We present our three-year experience with this system, which identifies drugs in less than 1 h, with a high degree of confidence.