Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microarray-based DNA profiling to study genomic aberrations.

Nic Waddell1

  • 1Queensland Institute of Medical Research, Queensland, Australia. nic.waddell@qimr.edu.au

IUBMB Life
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell.

Nature immunology·2024
Same author

Increased amphiregulin expression by CD4<sup>+</sup> T cells from individuals with asymptomatic <i>Leishmania donovani</i> infection.

Clinical & translational immunology·2022
Same author

Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis.

Cell reports·2020
Same author

Running Genomic Analyses in the Cloud.

Studies in health technology and informatics·2019
Same author

The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.

Journal of the National Cancer Institute·2018
Same author

Next-Generation Sequencing of Endobronchial Ultrasound Transbronchial Needle Aspiration Specimens in Lung Cancer.

American journal of respiratory and critical care medicine·2017
Same journal

ALKBH4 Promotes Osteogenesis via Epigenetic Regulation of BMP2-Wnt/β-Catenin Signaling in Cervical Spine OPLL.

IUBMB life·2026
Same journal

Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes.

IUBMB life·2026
Same journal

Mechanism of PCSK9-Mediated Macrophage Activation via the CAP1/NF-κB Pathway in CAWS-Induced Kawasaki Disease Vasculitis.

IUBMB life·2026
Same journal

Hormesis and the Golden Ratio: Toward a Universal Estimator of Adaptive Capacity.

IUBMB life·2026
Same journal

MicroRNAs in HPV-Associated Carcinogenesis: Potential Biomarkers in Oropharyngeal and Cervical Cancers.

IUBMB life·2026
Same journal

PGAM1 Orchestrates Cell Cycle Progression, Glycolytic Reprogramming, and Immunosuppressive Microenvironment in Triple-Negative Breast Cancer.

IUBMB life·2026
See all related articles

Microarray technology, initially for RNA analysis, now enables high-resolution genome-wide DNA alteration assessment. This evolution provides insights into human diseases and future research directions.

Area of Science:

  • Genomics
  • Molecular Biology
  • Biotechnology

Background:

  • Microarrays were first developed for parallel RNA expression analysis.
  • The technology has been adapted for genomic analysis, including DNA dosage and sequence content.
  • Advances in fabrication and sequencing projects have spurred affordable, high-resolution genome-wide DNA alteration assessment.

Purpose of the Study:

  • To review the evolution of microarray assays for studying genomic aberrations.
  • To highlight the insights gained into human disease biology using these methods.
  • To discuss the future benefits of microarray technology in research.

Main Methods:

  • Review of microarray assay development for genomic aberration studies.
  • Analysis of applications in understanding DNA dosage and sequence content.

Related Experiment Videos

  • Discussion of technological advancements in microarray fabrication and genome sequencing.

    • Main Results:

    • Microarrays have evolved from RNA analysis to high-resolution genome-wide DNA alteration assessment.
    • These advancements offer affordable array-based methods for genomic analysis.
    • The technology provides significant insights into the biology of human diseases.

    Conclusions:

    • Microarray technology has significantly advanced genomic research.
    • These methods offer powerful tools for understanding human disease biology.
    • Future applications promise further benefits for biomedical research.