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Cervical esophageal web and celiac disease
Saroj Kant Sinha1, Chander Kamal Nain, Harsh Prasad Udawat
1Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. sarojksinha@hotmail.com
Journal of Gastroenterology and Hepatology
|June 17, 2008
Summary
Adults with cervical esophageal webs and iron deficiency should be screened for celiac disease, even without diarrhea. This study found a significant association between these conditions, highlighting the need for proactive screening.
Area of Science:
- Gastroenterology
- Esophageal Disorders
- Autoimmune Diseases
Background:
- Cervical esophageal webs are rare, and their association with celiac disease is not well-established.
- Prospective data on screening asymptomatic patients with cervical esophageal webs for celiac disease is limited.
Purpose of the Study:
- To investigate the association between cervical esophageal webs and celiac disease.
- To determine if screening for celiac disease is warranted in all patients with cervical esophageal webs.
Main Methods:
- Prospective study of consecutive patients with symptomatic cervical esophageal webs.
- Serum tissue transglutaminase antibody testing, followed by esophagogastroduodenoscopy and duodenal biopsies if elevated.
- Diagnosis of celiac disease based on serology and histology.
Main Results:
- Twenty-one patients with cervical esophageal webs were identified.
- Celiac disease was diagnosed in 5 (23.8%) patients, all of whom had iron deficiency.
- None of the celiac disease patients reported chronic diarrhea.
Conclusions:
- A significant association exists between cervical esophageal webs and celiac disease.
- Adult patients with cervical esophageal webs and iron deficiency should be screened for celiac disease, irrespective of gastrointestinal symptoms.
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