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Updated: Sep 10, 2025
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qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
Published on: March 6, 2019
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Identification of KIR3DL1*0080105, KIR3DL1*0150224 and KIR2DL4*060 by Next Generation Sequencing
Disha Agarwal1, Gaurav Sharma1, Alka Khadwal2
1Department of Translational and Regenerative Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
HLA
|August 27, 2025
Summary
Novel KIR3DL1 and KIR2DL4 gene variants were identified in healthy Indian individuals. This discovery contributes to understanding KIR gene diversity within this specific population.
Area of Science:
- Immunogenetics
- Human Population Genetics
Background:
- Killer cell immunoglobulin-like receptors (KIRs) are crucial for immune system regulation.
- KIR gene polymorphisms exhibit significant ethnic and population-specific variations.
Purpose of the Study:
- To identify and characterize novel KIR gene alleles in the Indian population.
- To expand the catalog of known KIR alleles.
Main Methods:
- High-resolution KIR genotyping was performed.
- Sequence-based typing methods were employed for allele identification.
Main Results:
- Three novel KIR alleles were identified: KIR3DL1*0080105, KIR3DL1*0150224, and KIR2DL4*060.
- These novel alleles were found in healthy individuals of Indian ancestry.
Conclusions:
- The identification of these novel alleles highlights the genetic diversity of KIR genes in India.
- This finding is important for future immunogenetic studies and potential clinical applications in the region.
