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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

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Kidney Procurement in a Preclinical Large Animal Model
05:36

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Published on: May 2, 2025

Can machine perfusion decrease the likelihood of discard among biopsied kidneys?

Y W Cho1, S Bunnapradist, E S Cho

  • 1National Institute of Transplantation, Los Angeles, California 90057, USA.

Transplantation Proceedings
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

Kidney biopsies identify factors predicting discard, with glomerulosclerosis over 20% being a key indicator. Machine perfusion (MP) significantly reduced discard rates compared to cold storage for biopsied kidneys.

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Last Updated: Jul 4, 2026

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Published on: July 15, 2015

Area of Science:

  • Nephrology
  • Transplantation Science
  • Pathology

Background:

  • Donor risk factors and renal function influence deceased donor kidney discard.
  • Renal biopsy is used when other factors are insufficient to assess kidney suitability.
  • Identifying predictors of kidney discard is crucial for optimizing organ utilization.

Purpose of the Study:

  • To identify factors predicting the discard of biopsied kidneys from deceased donors.
  • To assess the impact of machine perfusion (MP) on kidney discard rates.

Main Methods:

  • Logistic regression analysis was used to evaluate predictors of kidney discard.
  • 678 kidneys from deceased donors aged >=40 years were biopsied between 2001-2006.
  • Comparison of discard rates between machine perfusion (MP) and cold storage (CS) groups.

Main Results:

  • 39% of biopsied kidneys were discarded.
  • Glomerulosclerosis (GS) > 20% was the strongest predictor of discard.
  • Other predictors included donor age, final resistance, atherosclerosis, fibrosis, arteriolosclerosis, and serum creatinine.
  • MP kidneys showed a significantly lower discard rate (adjusted odds ratio = 0.13, P < .001) compared to CS kidneys.

Conclusions:

  • Abnormal renal biopsy findings, particularly severe glomerulosclerosis, are associated with high kidney discard likelihood.
  • Machine perfusion (MP) use, although limited to 10% of cases, was linked to reduced discard rates.
  • MP may be a valuable strategy to improve the utilization of biopsied donor kidneys.