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Related Experiment Videos

Can machine perfusion decrease the likelihood of discard among biopsied kidneys?

Y W Cho1, S Bunnapradist, E S Cho

  • 1National Institute of Transplantation, Los Angeles, California 90057, USA.

Transplantation Proceedings
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

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Kidney biopsies identify factors predicting discard, with glomerulosclerosis over 20% being a key indicator. Machine perfusion (MP) significantly reduced discard rates compared to cold storage for biopsied kidneys.

Area of Science:

  • Nephrology
  • Transplantation Science
  • Pathology

Background:

  • Donor risk factors and renal function influence deceased donor kidney discard.
  • Renal biopsy is used when other factors are insufficient to assess kidney suitability.
  • Identifying predictors of kidney discard is crucial for optimizing organ utilization.

Purpose of the Study:

  • To identify factors predicting the discard of biopsied kidneys from deceased donors.
  • To assess the impact of machine perfusion (MP) on kidney discard rates.

Main Methods:

  • Logistic regression analysis was used to evaluate predictors of kidney discard.
  • 678 kidneys from deceased donors aged >=40 years were biopsied between 2001-2006.
  • Comparison of discard rates between machine perfusion (MP) and cold storage (CS) groups.

Related Experiment Videos

Main Results:

  • 39% of biopsied kidneys were discarded.
  • Glomerulosclerosis (GS) > 20% was the strongest predictor of discard.
  • Other predictors included donor age, final resistance, atherosclerosis, fibrosis, arteriolosclerosis, and serum creatinine.
  • MP kidneys showed a significantly lower discard rate (adjusted odds ratio = 0.13, P < .001) compared to CS kidneys.

Conclusions:

  • Abnormal renal biopsy findings, particularly severe glomerulosclerosis, are associated with high kidney discard likelihood.
  • Machine perfusion (MP) use, although limited to 10% of cases, was linked to reduced discard rates.
  • MP may be a valuable strategy to improve the utilization of biopsied donor kidneys.