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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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Behavioural sensitization in mice induced by morphine-glucuronide metabolites

Marte Handal1, Ase Ripel, Svetlana Skurtveit

  • 1Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, P.O. Box 4404 Nydalen, NO-0403 Oslo, Norway. marte.handal@fhi.no

Pharmacology, Biochemistry, and Behavior
|June 17, 2008
PubMed
Summary

Morphine-6-glucuronide (M6G) causes long-lasting locomotor sensitization similar to morphine. Morphine-3-glucuronide (M3G) also sensitizes morphine-induced activity, suggesting these metabolites contribute to opioid addiction.

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