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Related Experiment Video

Updated: Jul 4, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

Gold nanoparticles in delivery applications.

Partha Ghosh1, Gang Han, Mrinmoy De

  • 1Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA, 01003, USA.

Advanced Drug Delivery Reviews
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

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Gold nanoparticles (AuNPs) offer safe drug and gene delivery. Their unique properties enable controlled release inside cells, enhancing therapeutic potential.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Gold nanoparticles (AuNPs) are increasingly explored for biomedical applications due to their unique optical and physical properties.
  • Non-toxic carriers are essential for effective drug and gene delivery systems.
  • Controlled intracellular release mechanisms are crucial for targeted therapies.

Purpose of the Study:

  • To highlight the potential of gold nanoparticles (AuNPs) as non-toxic carriers for drug and gene delivery.
  • To discuss the tunable surface properties of AuNPs for optimized delivery systems.
  • To explore the mechanism of thiol-mediated intracellular release from AuNP carriers.

Main Methods:

  • Characterization of gold nanoparticle synthesis and surface functionalization.

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Related Experiment Videos

Last Updated: Jul 4, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
10:46

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

  • Evaluation of AuNP stability and surface property modulation (charge, hydrophobicity).
  • Investigation of AuNP interaction with biological thiols for controlled release studies.

    • Main Results:

    • Gold nanoparticles demonstrate excellent stability due to their gold core.
    • Surface monolayers allow precise tuning of nanoparticle surface properties.
    • Selective interaction with thiols facilitates controlled intracellular drug/gene release.

    Conclusions:

    • Gold nanoparticles are promising non-toxic carriers for drug and gene delivery.
    • Tunable surface properties and thiol-mediated release offer advantages for targeted therapies.
    • AuNPs represent a versatile platform for advanced intracellular delivery systems.