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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Updated: Jun 29, 2026

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
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Published on: March 13, 2012

[Neuropathic pain in the elderly].

Gisèle Pickering1, Françoise Capriz-Ribière

  • 1Centre de Pharmacologie Clinique, Inserm CIC 501, CHU de Clermont-Ferrand, France. gisele.pickering@u-clermont1.fr

Psychologie & Neuropsychiatrie Du Vieillissement
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Summary

Neuropathic pain significantly impacts older adults, presenting treatment challenges due to comorbidities and polypharmacy. Integrated pharmacological and non-pharmacological strategies are crucial for managing this complex condition in the elderly.

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Area of Science:

  • Gerontology
  • Pain Medicine
  • Neurology

Context:

  • Neuropathic pain affects approximately 9% of individuals aged 65 and older.
  • Conditions common in the elderly, such as diabetes, shingles, stroke, and surgery, can lead to neuropathic pain.
  • Effective pain management in older adults is complicated by age-related factors and frequent co-existing medical conditions.

Purpose:

  • To highlight the challenges in treating neuropathic pain in the elderly population.
  • To emphasize the need for integrated therapeutic strategies, considering cognitive, emotional, and physical aspects.
  • To underscore the scarcity of dedicated research on neuropathic pain specifically in older adults.

Summary:

  • Neuropathic pain in the elderly is more intense and prolonged than other chronic pain types.
  • Treatment is complex due to difficulties in pain assessment, polypharmacy, and associated health issues.
  • Cognition, emotion, and physical activity are vital for autonomy and must be integrated into treatment plans.

Impact:

  • Calls for more epidemiological studies and controlled clinical trials focused on neuropathic pain in the elderly.
  • Suggests the development of evidence-based, multimodal therapeutic strategies.
  • Aims to improve the quality of life and autonomy for elderly individuals suffering from neuropathic pain.