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Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
11:57

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

Spinal reconstruction in Hajdu-Cheney syndrome

Catherine Murtagh-Schaffer1, Ross R Moquin

  • 1Resarch Foundation of the State University of New York Upstate Medical Center, Syracuse, USA.

JAAPA : Official Journal of the American Academy of Physician Assistants
|June 18, 2008
PubMed
Abstract

No abstract available in PubMed .

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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