Related Experiment Videos
[Induction of autoreactive T-cells by bacterial stress proteins in HLA-DR4 donors]
C Epplen1, R Mitreiter, H Hatz
1Max-Planck-Institut für Psychiatrie, Martinsried.
From the peripheral blood of HLA-DR4+ healthy donors or patients with rheumatoid arthritis autoreactive T-cell lines were obtained after stimulation with bacterial heat-shock protein. All lines obtained express an alpha/beta-T-cell receptor and they are predominantly CD4+. The determination of the fine specificity of those autoreactive T cells showed, that either amino-acid position #71 or #86 of the HLA-DR beta 1 chain was critical for recognition by the antigen receptor.
From the peripheral blood of HLA-DR4+ healthy donors or patients with rheumatoid arthritis autoreactive T-cell lines were obtained after stimulation with bacterial heat-shock protein. All lines obtained express an alpha/beta-T-cell receptor and they are predominantly CD4+. The determination of the fine specificity of those autoreactive T cells showed, that either amino-acid position #71 or #86 of the HLA-DR beta 1 chain was critical for recognition by the antigen receptor.