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Is octreotide a risk factor in necrotizing enterocolitis?

Carlos A Reck-Burneo1, Aruna Parekh, Francisca T Velcek

  • 1Long Island College Hospital, Brooklyn, NY 11201, USA. crmd@burneo.com

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|June 19, 2008
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Octreotide is a second-line treatment for hyperinsulinemic hypoglycemia. This case report details a newborn who developed massive enterocolitis after octreotide treatment, requiring multiple surgeries.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Hyperinsulinemic hypoglycemia in neonates often requires pharmacologic intervention.
  • Diazoxide is a first-line therapy, with octreotide used for refractory cases.
  • Octreotide's efficacy is established, but potential adverse effects require monitoring.

Observation:

  • A full-term newborn with refractory hypoglycemia was treated with octreotide.
  • The infant subsequently developed massive enterocolitis.
  • This necessitated extensive surgical intervention to preserve intestinal length and function.

Findings:

  • The development of massive enterocolitis occurred following the initiation of octreotide therapy.
  • This adverse event highlights a potential gastrointestinal complication associated with octreotide use in neonates.
  • Surgical management was critical for mitigating the severity of the enterocolitis.

Implications:

  • Clinicians should consider the risk of enterocolitis when prescribing octreotide for neonatal hypoglycemia.
  • Further investigation into the mechanism linking octreotide to neonatal enterocolitis is warranted.
  • This case underscores the importance of vigilant monitoring for gastrointestinal adverse events in neonates receiving octreotide.