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Updated: Jul 4, 2026
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Published on: January 9, 2026
[Prognostic value of lymph node dissections in bladder cancer treated with radical cystectomy]
1Clinique urologique, CHU Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex, France.
Objective:
The objective of this retrospective study was to analyse the impact of lymph node invasion on survival after radical cystectomy for bladder cancer.
Material And Methods:
From 1988 to 2002, 192 patients underwent radical cystectomy for bladder cancer. Lymph node dissection was performed in 144 patients (75%) with bilateral pelvic lymph node dissection in 130 patients and extension to iliac chains in 14 patients.
Results:
Lymph node dissection had no impact on medical or surgical morbidity. Lymph node invasion was demonstrated in 35.4% of cases (51/144). Tumour effraction of the lymph node capsule was reported in 70.6% (36/51) of pN+ patients. Lymph node invasion was reported in 16.7% of pT0 patients, 0% of pTa, pTis, pT1 patients and 40, 47 and 48% of pT2, pT3 and pT4 patients, respectively. The mean follow-up was 40.3+/-3.5 months (median: 26.6; range 0-207 months). Overall, specific and recurrence-free survivals were significantly influenced by lymph node invasion (p<0.0001, p<0.0001, p<0.0001, respectively) and capsular effraction (p=0.0021, p=0.0027, p=0.0113, respectively).
Conclusion:
Lymph node invasion and especially capsular effraction were significant prognostic factors of overall specific and recurrence-free survival.