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Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...

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Related Experiment Video

Updated: Jul 4, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

[BIRD: a large database using renal function parameters in France].

J Cogneau1, F Blanchecotte, J-M Halimi

  • 1Service de néphrologie-immunologie clinique, hôpital Bretonneau, CHU Tours, France.

Annales De Biologie Clinique
|June 19, 2008
PubMed
Summary
This summary is machine-generated.

Mild renal dysfunction is common in older adults, affecting 10% of those 60+ and up to 75% of those 75+. Early identification and management of kidney disease are crucial for preventing cardiovascular complications.

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Last Updated: Jul 4, 2026

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Area of Science:

  • Nephrology
  • Epidemiology
  • Public Health

Context:

  • Rising incidence of end-stage renal disease in Western countries.
  • Limited data on mild renal dysfunction in the general population.
  • Need for comprehensive renal function assessment.

Purpose:

  • To establish a database of creatinine measurements in the Région Centre, France.
  • To assess the prevalence of mild renal dysfunction using the Cockcroft formula.
  • To evaluate the correlation between renal risk and cardiovascular risk.

Summary:

  • Collected over 100,000 creatinine measurements from ~70,000 patients across 27 laboratories.
  • Prevalence of estimated glomerular filtration rate < 60 mL/min was 10% (60+), 25% (70+), and 75% (75+).
  • Patients with renal risk factors also exhibited high cardiovascular risk, but were often undiagnosed.

Impact:

  • Highlights delayed diagnosis and management of renal dysfunction.
  • Underscores the need for improved renal function assessment and patient management strategies.
  • Emphasizes the link between renal and cardiovascular health, necessitating integrated care approaches.