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Changes of nerve excitability and urinary deltamethrin in sprayers
1Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
International Archives of Occupational and Environmental Health
|January 1, 1991
Summary
Deltamethrin sprayers showed prolonged median nerve supernormal periods after exposure, indicating potential neurotoxicity. This effect was measurable even without acute poisoning symptoms, suggesting a sensitive indicator for deltamethrin exposure.
Area of Science:
- Neuroscience
- Toxicology
- Environmental Health
Background:
- Deltamethrin is a widely used insecticide.
- Assessing deltamethrin's neurotoxic effects in occupationally exposed individuals is crucial.
- Biomonitoring of deltamethrin and its metabolites is important for exposure assessment.
Purpose of the Study:
- To evaluate the exposure and neurotoxic effects of deltamethrin in sprayers.
- To assess changes in median nerve excitability following deltamethrin exposure.
- To correlate nerve excitability changes with urinary deltamethrin and metabolite levels.
Main Methods:
- Urine samples analyzed for deltamethrin and metabolite Br2A using GC and HPLC.
- Median nerve excitability measured using electromyography with paired stimuli.
- Comparison of nerve excitability before, during, and after deltamethrin spraying in exposed vs. unexposed groups.
Main Results:
- Urinary deltamethrin and Br2A were detected in exposed sprayers.
- A significant prolongation of the median nerve supernormal period was observed in sprayers post-exposure.
- No significant changes in nerve excitability were found in the unexposed reference group.
Conclusions:
- Deltamethrin exposure can alter median nerve excitability, specifically prolonging the supernormal period.
- Nerve excitability testing offers a potentially valuable, non-invasive method for monitoring deltamethrin toxicity.
- Further research is needed to understand the correlation between exposure levels and neurophysiological changes.