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Updated: Apr 27, 2026
Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
Published on: May 29, 2015
[Establishment of modified abdominal heart transplantation model in rats]
1Department of Gastroenterology, The 6th Affiliated Hospital, Guangzhou, China. yusi1976111@yahoo.com.cn
Objective:
To investigate the techniques of establishment of abdominal heart transplantation model in rats and modify the procedure to make it more stable and improve the success rate.
Methods:
Heterotopic abdominal heart transplantations of Wistar and SD rats were performed by using Ono's method with modification of preparation of recipients, donor cardiectomy and donor transplantations.
Results:
One hundred heart transplantations were performed, among which 90 were successful. The success rate was 90%.
Conclusion:
This modified Ono's method can shorten the ischemia time and recipient abdominal aorta occlusion time, make vessel anastomosis easier and increase the success rate of operation. It is a stable and reliable model of heart transplantations in rats.
