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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Updated: Jul 4, 2026

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

p63 in epithelial development.

E Candi1, R Cipollone, P Rivetti di Val Cervo

  • 1Biochemistry Laboratory IDI-IRCCS and University of Rome 'Tor Vergata', via Montpellier 1, 00133, Rome, Italy. candi@uniroma2.it

Cellular and Molecular Life Sciences : CMLS
|June 19, 2008
PubMed
Summary
This summary is machine-generated.

The transcription factor p63 is crucial for skin development and barrier function. Understanding its roles, including TAp63 and DeltaNp63, advances knowledge of epidermal morphogenesis and related diseases.

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Last Updated: Jul 4, 2026

Establishment of a Clinic-based Biorepository
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Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
07:29

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

Published on: May 16, 2020

Area of Science:

  • Dermatology
  • Developmental Biology
  • Genetics

Background:

  • The epidermis, the skin's outer layer, is a stratified epithelium critical for protection.
  • Keratinocytes form the epidermis, and their development is regulated by the p63 transcription factor.
  • The Trp63 gene produces TAp63 and DeltaNp63 isoforms with distinct roles in epidermal development.

Purpose of the Study:

  • To review current understanding of p63's role in epidermal morphogenesis.
  • To explore the functions of TAp63 and DeltaNp63 isoforms.
  • To connect p63 function to ectodermal dysplasia pathogenesis.

Main Methods:

  • Literature review of studies on p63 and epidermal development.
  • Analysis of research on Trp63 gene promoters and protein isoforms.
  • Synthesis of findings related to p63 mutations and ectodermal dysplasia.

Main Results:

  • p63 is essential for epidermal stratification and development.
  • Distinct roles of TAp63 and DeltaNp63 in epidermal morphogenesis are being elucidated.
  • Mutations in Trp63 are linked to ectodermal dysplasia.

Conclusions:

  • p63 plays a vital role in skin development and barrier formation.
  • Further research into p63 isoforms will clarify epidermal development.
  • Understanding p63 is key for treating ectodermal dysplasia.