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Updated: Jul 4, 2026

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Published on: October 18, 2011

Post-operative radiotherapy for Ewing sarcoma: when, how and how much?

S Laskar¹, I Mallick, T Gupta

¹Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai 400012, India. laskars2000@yahoo.com

Pediatric Blood & Cancer

|June 19, 2008

Summary

Postoperative radiotherapy (PORT) for Ewing tumors is evolving. This review examines evidence to define current standards and controversies in PORT, including indications, dosing, and late effects.

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Area of Science:

Oncology
Radiation Oncology
Pediatric Oncology

Background:

Postoperative radiotherapy (PORT) plays a crucial role in managing Ewing tumors.
Its application and techniques have evolved significantly over decades.
Optimal use in combined modality treatment remains an area of active research.

Purpose of the Study:

To review current evidence on postoperative radiotherapy for Ewing tumors.
To identify established standards and ongoing controversies in PORT.
To discuss future directions in the management of these tumors.

Main Methods:

Systematic review of major multi-institutional prospective trials.
Analysis of large retrospective institutional series.
Evaluation of data on indications, dose-fractionation, timing, target volumes, and late effects.

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Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

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Published on: October 18, 2011

Main Results:

Evidence-based consensus on current PORT standards is presented.
Key controversies regarding PORT indications and techniques are highlighted.
Late effects of PORT are reviewed in detail.

Conclusions:

The role of PORT in Ewing tumors continues to evolve.
Further research is needed to resolve current controversies and optimize treatment.
A comprehensive understanding of PORT is essential for combined modality management.