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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

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A Rat Model of Compound Acne
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Evaluating hyperandrogenism: a challenge in acne management.

Julie C Harper1

  • 1University of Alabama, Birmingham, AL, USA. juharper@yahoo.com

Journal of Drugs in Dermatology : JDD
|June 20, 2008
PubMed
Summary

Acne vulgaris can indicate excess androgens (hyperandrogenism). Evaluating patients requires a thorough history, physical exam, and laboratory screening for hormonal imbalances when signs of androgen excess are present.

Area of Science:

  • Endocrinology
  • Dermatology

Background:

  • Acne vulgaris is a common skin condition.
  • Hyperandrogenism, characterized by excess androgens, can manifest as acne vulgaris.
  • Understanding normal androgen production is key to identifying abnormalities.

Purpose of the Study:

  • To outline the evaluation of acne vulgaris as a potential sign of hyperandrogenism.
  • To emphasize the importance of clinical assessment and laboratory testing.

Main Methods:

  • Review of clinical presentation of acne vulgaris.
  • Assessment of diagnostic criteria for hyperandrogenism.
  • Guidance on appropriate laboratory screening for hormonal abnormalities.

Main Results:

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  • Clinical signs of androgen excess are crucial indicators.
  • A comprehensive history and physical examination are essential first steps.
  • Hormonal evaluation is imperative when clinical signs are present.
  • Conclusions:

    • Acne vulgaris warrants evaluation for underlying hyperandrogenism.
    • A systematic approach combining clinical assessment and laboratory testing is necessary.
    • Identifying and managing hyperandrogenism is critical for effective acne treatment.