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Updated: Jul 4, 2026

An Isolated Working Heart System for Large Animal Models
Published on: June 11, 2014
In vitro technique in estimation of passive mechanical properties of bovine heart part I. Experimental techniques and
Hamid Ghaemi1, K Behdinan, A D Spence
1Department of Mechanical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4L7. hghaemi@ryerson.ca
Abstract:
Myocardium generally demonstrates viscoelastic behavior. Since the stress-stain relationships of tissues are pseudo-elastic, their mechanical behavior can be defined as hyperelastic. In this work, mechanical properties of bovine heart were studied. In this study, the experimental technique for testing myocardium is explained and the experimental data are presented. First, the heart was perfused and the specimens were cut from different regions of the heart. Second, the materials preferred direction was identified. Then, a series of uniaxial, biaxial and equibiaxial test were performed on specimens taken from: left ventricle free wall (LVFW), right ventricle free wall (RVFW), left ventricle mid-wall (LVMW) and apex. Test specimens were preconditioned by applying cyclic load to reduce the viscoelastic effect. After preconditioning, the samples were tested at various stretch rates and loading conditions. Finally, a conclusion is made on the experimental data.

