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Solid-phase synthesis of a lysine-capped bis-dendron with remarkable DNA delivery abilities

Siew-Eng How1, Asier Unciti-Broceta, Rosario M Sánchez-Martín

  • 1School of Chemistry, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, UK.

Organic & Biomolecular Chemistry
|June 20, 2008
PubMed

Abstract:

Solid-phase synthesis of a generation 3.0 polyamidourea 1-->3 C-branched bis-dendron followed by capping of the peripheral amino groups with L-lysine gave an efficient transfection reagent.

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