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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Decrease in CD4+CD25+ and CD8+CD28+ T cells in interstitial pneumonitis associated with rheumatic disease.

Akira Katagiri¹, Shinji Morimoto, Yutaka Nakiri

¹Department of Internal Medicine and Rheumatology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Modern Rheumatology

|June 20, 2008

Summary

This summary is machine-generated.

Patients with interstitial pneumonitis (IP) linked to rheumatic diseases show fewer CD4+CD25+ regulatory T cells and more CD8+CD28- suppressor T cells. These T cell imbalances may contribute to IP development in rheumatic conditions.

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

Area of Science:

Immunology
Rheumatology
Pulmonology

Background:

Interstitial pneumonitis (IP) is a serious complication in rheumatic diseases.
The roles of regulatory T cells (CD4+CD25+) and suppressor T cells (CD8+CD28-) in IP pathogenesis are not fully understood.

Purpose of the Study:

To investigate the levels of CD4+CD25+ regulatory T cells and CD8+CD28- suppressor T cells in patients with rheumatic diseases and interstitial pneumonitis.
To explore the relationship between these T cell populations and the development of IP.

Main Methods:

Flow cytometry was used to analyze T cell subsets.
Fifty-five patients with rheumatic diseases (with or without IP) and 23 healthy controls were studied.

Main Results:

Patients with IP had significantly lower CD4+CD25+ T cell counts compared to non-IP patients.
The ratio of CD8+CD28- T cells was significantly higher in IP patients versus non-IP patients and controls.
Decreased CD8+CD28+ T cells were observed, potentially linked to activation-induced cell death.

Conclusions:

Abnormalities in CD4+CD25+ regulatory T cells may play a role in the pathogenesis of IP in rheumatic diseases.
Altered survival and activation of CD8+ T cells, specifically the CD8+CD28- subset, are associated with IP.