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Published on: June 21, 2018
Diversity-oriented synthesis
Richard J Spandl1, Mónica Díaz-Gavilán, Kieron M G O'Connell
1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Abstract:
Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation. We describe some of the most successful strategies utilized in DOS, with special focus on our own area of interest; DOS from simple, pluripotent starting materials.
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