Low frequency of renal artery disease in young ischemic stroke patients
1Stroke Section, Department of Neurology, Chang Gung Memorial Hospital, LinKou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Insights
Renal artery disease is uncommon in young ischemic stroke patients and not linked to typical risk factors. However, it is associated with intracranial carotid and coronary artery disease.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Vascular Surgery
Background:
- Renal artery disease (RAD) in young ischemic stroke patients remains understudied.
- Associated risk factors and vascular comorbidities of RAD in this demographic are not well understood.
Purpose of the Study:
- To investigate the frequency of renal artery disease in patients with ischemic stroke under 50 years old.
- To identify associated vascular risk factors and comorbidities in young ischemic stroke patients with renal artery disease.
Main Methods:
- Retrospective review of 152 ischemic stroke patients aged 50 or younger.
- Inclusion of 30 older ischemic stroke patients as controls.
- Performance of cerebral angiography and abdominal aortography to assess renal, cerebral, and coronary artery stenosis.
Main Results:
- Renal artery disease was found in 4.6% of younger patients, with 1.3% having significant stenosis.
- No significant association was observed between renal artery disease and traditional vascular risk factors (p > 0.05).
- A higher frequency of renal artery disease was noted in patients with intracranial carotid and coronary artery disease (p < 0.05).
Conclusions:
- The prevalence of renal artery disease is low among younger ischemic stroke patients.
- Intracranial carotid artery disease and coronary artery disease are associated with renal artery disease in this population.
Background:
The frequency, associated risk factors and associated vascular disorders in renal artery disease have not been studied in young ischemic stroke patients.
Methods:
From February 1999 to June 2006, we retrospectively reviewed a total of 152 younger ischemic stroke patients (< or = 50 y/o). Another 30 older ischemic stroke patients (age > 50 y/o) were randomly selected and studied as controls. All 182 patients received cerebral angiography and concomitant abdominal aortography. The extent of vascular stenosis was calculated for the renal, cerebral and coronary arteries. Vascular risk factors were also studied.
Results:
Of the 152 younger patients, seven (4.6%) patients had renal artery disease including two (1.3%) with significant stenosis. There was no association between renal artery disease and vascular risk factors (p > 0.05). Patients with intracranial carotid and coronary artery disease had a significantly higher frequency of renal artery disease (p < 0.05).
Conclusion:
Our results suggest that the frequency of renal artery disease is low in younger ischemic stroke patients. Intracranial carotid and coronary artery disease is associated with renal artery disease.
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