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Published on: March 30, 2017
Spray drying TB vaccines for pulmonary administration
P B Fourie1, W A Germishuizen, Y-L Wong
1Chief Scientific Officer Medicine in Need (Mend), MRC Building, PO Box 12660, Queenswood, 0121 Pretoria, South Africa. bfourie@medicineinneed.org
Background:
New developments in materials science provide innovative technologies that allow mucosal immunization against tuberculosis. Recent studies report that spray-drying Mycobacterium bovis Bacillus Calmette-Guérin (BCG) allows efficient aerosol delivery of TB vaccines to the lung.
Objectives:
To consider powder formulation of BCG for inhalation by spray-drying and its potential application to other vaccines given the unique challenges in the process, formulation and delivery.
Methods:
Description of current advances in spray-drying and aerosol delivery, and its application to preparation of BCG TB vaccine for inhalation. Special consideration is given to physical properties, viability, stability and delivery aspects.
Results/Conclusion:
Spray-drying generates powders with excellent dispersion qualities suitable for targeted delivery to the deep lung. TB vaccine for inhalation prepared by spray-drying is feasible, low-cost and pharmaceutically scaleable.
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