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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Updated: Jul 4, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
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Published on: June 28, 2019

[Gliomas in the elderly].

F Laigle-Donadey1, S Navarro, J-Y Delattre

  • 1Service de neurologie Mazarin, hôpital de la Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. florence.laigle-donadey@psl.aphp.fr

Revue Neurologique
|June 21, 2008
PubMed
Summary
This summary is machine-generated.

Malignant glioma incidence is rising in older adults. Recent studies show radiation therapy, particularly accelerated courses, benefits this group, though chemotherapy

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Area of Science:

  • Geriatric oncology
  • Neuro-oncology
  • Clinical trial design

Context:

  • Malignant gliomas disproportionately affect the elderly, a demographic often excluded from clinical research.
  • Age is a significant negative prognostic factor for glioma patients.
  • Optimal treatment strategies for elderly glioma patients are not well-established.

Purpose:

  • To review current evidence and evolving treatment paradigms for malignant gliomas in the elderly population.
  • To highlight the growing importance of active treatment strategies over historical nihilistic approaches.

Summary:

  • Prospective studies confirm the efficacy of radiation therapy, including accelerated regimens, for older patients with malignant gliomas.
  • The role of chemotherapy, alone or combined with radiation, is still under investigation for this demographic.
  • Patient factors such as performance status, quality of life, and comorbidities are crucial for treatment decisions.

Impact:

  • Shifts the management paradigm for elderly glioma patients towards more active and evidence-based interventions.
  • Emphasizes the need for tailored treatment protocols considering the unique characteristics of older patients.
  • Informs future research directions for optimizing care in this vulnerable population.