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Updated: Jul 4, 2026
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
[New therapeutic approaches in glioblastomas]
J Le Guilloux1, A-F Carpentier
1Service de neurologie de l'hôpital Avicenne, Assistance publique-Hôpitaux de Paris, 125, route de Stalingrad, 75013 Bobigny, France.
Abstract:
Current treatment of glioblastomas relies on surgical resection, radiotherapy and chemotherapy. However, the efficacy of these therapeutics is still limited and new therapeutic approaches based on the understanding of brain tumor biology are emerging. High expression of the EGF receptor by tumor cells, activation of the PI3K/Akt and the Ras/Raf pathways represent interesting targets for new selective drugs under development. The most promising drugs are currently antiangiogenic agents. This article reviews these emerging therapies currently under clinical trials in glioblastomas.
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