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Related Experiment Video

Updated: Jul 4, 2026

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

Affect regulation: a systems neuroscience perspective.

Mani N Pavuluri¹, Ellen S Herbener, John A Sweeney

¹Center for Cognitive Medicine, University of Illinois at Chicago Chicago, IL, USA. mpavuluri@psych.uic.edu

Neuropsychiatric Disease and Treatment

|June 24, 2008

Summary

This summary is machine-generated.

Integrating neuroanatomy, function, and bipolar disorder, this study highlights distinct prefrontal cortex roles in affect regulation. Dysregulation impacts cognition and motor control, suggesting potential therapeutic targets.

Keywords:

affect amygdala bipolar disorder child functional magnetic neuroimaging mania neuroanatomy prefrontal cortex

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Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Affect regulation involves complex neuroanatomical and functional models.
Bipolar disorder exemplifies affect dysregulation, impacting cognition and motor control.

Purpose of the Study:

To integrate neuroanatomical and functional models of affect regulation.
To examine affect dysregulation in bipolar disorder within these integrated models.

Main Methods:

Computerized literature search.
Augmentation with selected additional studies.

Main Results:

Orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) have distinct functions and connectivity.
Differential effects of positive and negative emotions on cognition observed.
Potential complementary activation of DLPFC and OFC by cognitive and affective stimuli, respectively, may be disrupted in disease.

Conclusions:

Prefrontal cortex subregions (OFC, DLPFC) have unique roles in affect regulation.
Bipolar disorder presents with complex affect dysregulation, cognitive deficits, and motoric issues.
Future research should explore the reversibility of affective circuitry dysfunction using neuroimaging and pharmacological interventions.