Related Experiment Video
Updated: Jul 4, 2026

A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice
Published on: April 19, 2016
Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx
Takao Hamamoto1, Masaya Takumida, Katsuhiro Hirakawa
1Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. hamamoto-takao@ams.odn.ne.jp
Conclusion:
Laryngeal epithelium contains TRPV1, 2, 3 and 4, which may act as laryngeal nociceptors perceiving luminal noxious stimuli, play an important role in thermal sensation, osmotic sensation, and are also related to pathological conditions, such as inflammatory response, genesis of cough, asthma.
Objective:
Expression of TRPV1, 2, 3 and 4 in the normal CBA/J mouse larynx was analysed.
Materials And Methods:
CBA/J mice were used in this study. The localizations of TRPV1, 2, 3 and 4 in the laryngeal epithelium were investigated by immunohistochemistry.
Results:
Immunohistochemical study revealed the presence of TRPV1, 2, 3 and 4 in the laryngeal epithelial cells. TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.
Related Concept Videos
Cholinergic Receptors: Muscarinic
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...
Olfactory Receptors: Location and Structure

