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Mechanism and treatment of sulfide-induced coma: a rat model
A F Almeida1, P N Nation, T L Guidotti
1Department of Public Health Sciences, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
International Journal of Toxicology
|June 24, 2008
Abstract:
Sodium hydrosulfide and dimethylsulfide duplicate the effects of hydrogen sulfide in causing coma in Sprague-Dawley rats and are additive for lethality. Nitrite, pyruvate and dithiothreitol had no significant effect on coma or lethality but bicarbonate with and without glucose reduced duration of coma. This finding suggests an antidotal treatment.
