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Ames test evaluation of two commercially available zero-valent nickel compounds
P David Josephy1, Jody J Weadge, Joseph Meissner
1Department of Molecular and Cellular Biology, College of Biological Science, University of Guelph, Guelph, Ontario, N1G 2W1 Canada. djosephy@uoguelph.ca
Mutation Research
|June 24, 2008
Summary
Zero-valent nickel compounds, used in synthesis and food processing, were evaluated for genotoxic effects. Studies found no evidence of mutagenicity or lipid peroxidation, suggesting these nickel compounds are not genotoxic.
Area of Science:
- Organometallic chemistry
- Toxicology
- Food science
Background:
- Zero-valent nickel compounds are organometallic chemicals with industrial applications.
- Their potential genotoxic effects, particularly in food processing, are not well-studied.
- This study investigates the genotoxicity of commercially available zero-valent nickel compounds.
Purpose of the Study:
- To assess the genotoxic potential of zero-valent nickel compounds.
- To evaluate the mutagenicity of bis(1,5-cyclooctadiene)nickel using the Ames assay.
- To investigate the impact of zero-valent nickel compounds on lipid peroxidation in bovine erythrocytes.
Main Methods:
- Solubility and stability of two commercial zero-valent nickel compounds were examined.
- Mutagenicity was tested using the Ames assay.
- In vitro studies exposed bovine erythrocytes to assess lipid peroxidation.
Main Results:
- Mutagenicity testing did not confirm previous reports for bis(1,5-cyclooctadiene)nickel in the Ames assay.
- No stimulation of lipid peroxidation was observed in bovine erythrocytes.
- The tested zero-valent nickel compounds exhibited no genotoxic effects under the study conditions.
Conclusions:
- Zero-valent nickel compounds do not appear to possess genotoxic properties based on current testing.
- These findings contribute to the safety assessment of nickel compounds in synthetic applications and food processing.
- Further research may explore other potential toxicological endpoints.
