Pan-Canadian consensus recommendations for GIST management in high- and low-throughput centres across Canada

Area of Science:

• Oncology
• Gastroenterology
• Molecular Pathology

Background:

• Gastrointestinal stromal tumours (GISTs) are mesenchymal neoplasms driven by specific mutations.
• Current GIST treatments include surgical resection and tyrosine kinase inhibitors.
• Inconsistent GIST management exists across Canadian provinces due to healthcare administration.

Purpose of the Study:

• To establish pan-Canadian guidance for GIST management.
• To harmonize clinical practice and standardize treatment approaches nationwide.
• To provide up-to-date data on GIST molecular and clinical features.

Main Methods:

• A panel of 20 Canadian physicians with GIST expertise reviewed relevant literature.
• Literature review focused on seven key domains: molecular profiling, imaging, localized therapy, systemic treatments, emerging tests, multidisciplinary care, and patient advocacy.
• Consensus was reached through literature review, clinical expertise, and expert opinion.

Main Results:

• The review synthesized current knowledge on GIST molecular drivers and treatment modalities.
• Key areas addressed include diagnostic techniques, therapeutic strategies, and the importance of multidisciplinary care.
• The paper outlines recommendations for standardized GIST management.

Conclusions:

• Standardized, evidence-based guidance is crucial for consistent GIST management in Canada.
• This consensus paper aims to harmonize clinical practice and improve patient outcomes.
• The recommendations will assist healthcare providers in the approach and management of GIST patients.