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You're too old for that.

Vinay A Shah1, Sandeep Randhawa, Thomas Mizen

  • 1Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242-1091, USA.

Survey of Ophthalmology
|June 24, 2008
PubMed
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Leber hereditary optic neuropathy (LHON), a mitochondrial disease, typically affects young men. This case highlights LHON in an older male, emphasizing broader diagnostic considerations for optic neuropathy.

Area of Science:

  • Ophthalmology
  • Genetics
  • Neurology

Background:

  • Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder causing vision loss.
  • Common LHON mutations involve mitochondrial DNA positions 11778, 14484, and 3460.
  • Typically, LHON presents in young to middle-aged men (20-40 years) with subacute, sequential optic neuropathy.

Observation:

  • This report details a case of LHON in a 72-year-old male patient.
  • The patient presented with unexplained bilateral and sequential optic neuropathy.

Findings:

  • The diagnosis of LHON was confirmed in an elderly patient, challenging the typical age demographic.
  • Genetic testing identified mutations consistent with LHON.

Implications:

Related Experiment Videos

  • This case underscores the importance of considering LHON in older individuals presenting with optic neuropathy.
  • Broadening the diagnostic criteria for LHON can improve patient outcomes.
  • Early diagnosis and genetic counseling are crucial for managing LHON patients and their families.