Related Experiment Video
Updated: Jul 4, 2026

Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
Published on: November 21, 2017
Calorimetry and thermodynamics in drug design
1James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA. j.chaires@louisville.edu
Abstract:
Modern instrumentation for calorimetry permits direct determination of enthalpy values for binding reactions and conformational transitions in biomolecules. Complete thermodynamic profiles consisting of free energy, enthalpy, and entropy may be obtained for reactions of interest in a relatively straightforward manner. Such profiles are of enormous value in drug design because they provide information about the balance of driving forces that cannot be obtained from structural or computational methods alone. This perspective shows several examples of the insight provided by thermodynamic data in drug design.
Related Concept Videos
Constant Pressure Calorimetry
Calorimetry
Constant Volume Calorimetry
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Biopharmaceutical Factors Influencing Drug Product Design: Overview
Measurement of Bioavailability: Pharmacokinetic Methods

