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Lymph node micrometastasis in node negative early gastric cancer.

J J Kim¹, K Y Song, H Hur

¹Department of Surgery, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Republic of Korea.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|June 25, 2008

Summary

The incidence of lymph node micrometastasis in node-negative early gastric cancer (EGC) was 10%. Lymphatic invasion and larger tumor size were identified as independent risk factors for micrometastasis in EGC patients.

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Area of Science:

Oncology
Gastroenterology
Surgical Pathology

Background:

The clinical significance of lymph node micrometastasis in node-negative gastric cancer requires further elucidation.
Early gastric cancer (EGC) staging is critical for treatment decisions and prognosis.

Purpose of the Study:

To assess the incidence of lymph node micrometastasis in node-negative EGC.
To identify independent risk factors associated with lymph node micrometastasis in EGC.

Main Methods:

Utilized anticytokeratin immunohistochemical staining to detect micrometastasis.
Investigated 90 patients with node-negative EGC who underwent curative resection (1991-2000).
Analyzed 3526 lymph nodes for micrometastatic deposits.

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Main Results:

Identified micrometastasis in 10% of patients (9 out of 90).
Micrometastasis incidence was significantly higher with lymphatic invasion (p=0.012), venous invasion (p=0.026), and larger tumor size (p=0.003).
Independent risk factors for micrometastasis were lymphatic invasion (RR=22.915) and tumor size (RR=1.493).

Conclusions:

The incidence of lymph node micrometastasis in node-negative EGC is 10%.
Lymphatic invasion and tumor size are significant independent risk factors for lymph node micrometastasis in EGC.
These findings aid in risk stratification for node-negative EGC patients.