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Updated: Jul 4, 2026
10:49
Intravital Longitudinal Imaging of Vascular Dynamics in the Calvarial Bone Marrow
Published on: April 11, 2025
Idiopathic calvarial thinning.
Satoshi Tsutsumi1, Yukimasa Yasumoto, Masanori Ito
1Department of Neurological Surgery, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan. shotaro@juntendo-urayasu.jp
Neurologia Medico-Chirurgica
|June 25, 2008
Summary
This study reports a rare case of progressive bilateral parietal calvarial thinning in an elderly diabetic woman. The cause remains undetermined despite extensive investigation, highlighting a complex bone remodeling mechanism.
Area of Science:
- Medical Case Study
- Radiology
- Histopathology
Background:
- Presents an 82-year-old female with a 6-year history of gradually enlarging, painless scalp depressions.
- Patient has well-controlled diabetes mellitus and no history of head trauma, inflammation, or malignancy.
Observation:
- Neuroimaging revealed symmetric thinning of bilateral parietal bones due to loss of diploe and outer table.
- Bone scintigraphy showed mild hypoaccumulation in the left calvarium.
- Histopathology demonstrated homogeneous membranous bone with regressed diploe, lacking osteoblasts, osteoclasts, or signs of malignancy.
Findings:
- The observed calvarial thinning is distinct from Gorham-Stout disease.
- Laboratory results, including calcium, magnesium, phosphorus, and hormone levels, were within normal limits.
- The case presents a unique pattern of bone loss without identifiable etiology.
Implications:
- Suggests an undetermined complex mechanism underlying idiopathic calvarial thinning.
- Highlights the importance of comprehensive diagnostic evaluation for unexplained bone abnormalities.
- Contributes to understanding rare bone remodeling disorders affecting the cranium.
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