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Updated: Jul 4, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction.

Barry A Boilson¹, Thomas J Kiernan, Adriana Harbuzariu

¹Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.

Nature Clinical Practice. Cardiovascular Medicine

|June 26, 2008

Summary

This summary is machine-generated.

Reduced circulating CD34+ progenitor cells, including specific subsets like CD34+/CD45(dim)/VEGFR2- cells, are linked to coronary endothelial dysfunction. These changes may signal early atherosclerosis development.

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Last Updated: Jul 4, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

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Published on: February 14, 2017

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Published on: April 15, 2020

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Area of Science:

Cardiovascular Research
Cell Biology
Atherosclerosis Research

Background:

Endothelial dysfunction is an early sign of atherosclerosis.
Circulating CD34+ cells, including progenitor cells, may influence atherosclerosis progression.
This study investigates the link between coronary endothelial dysfunction and circulating CD34+ cell subsets.

Purpose of the Study:

To evaluate the association between coronary endothelial dysfunction and circulating CD34+ cell subsets.
To identify specific CD34+ cell subsets altered in patients with endothelial dysfunction.
To explore the potential of these cell changes as early markers of atherosclerosis.

Main Methods:

Coronary endothelial function assessed via intracoronary acetylcholine challenge in 57 patients.
Mononuclear cells analyzed by flow cytometry for CD14, CD34, CD133, CD45, and VEGFR2.
Functional analysis of cultured cells, including colony-forming unit assays.

Main Results:

Patients with coronary endothelial dysfunction showed reduced numbers of circulating CD34+/CD45(dim)/VEGFR2- cells and CD34+/CD45(dim)/CD133+/VEGFR2- cells.
Reduced colony-forming units were observed in patients with endothelial dysfunction.
No significant difference in CD34+/CD45-/VEGFR2+ cell concentrations between groups.

Conclusions:

Circulating CD34+ cell subset regulation differs between patients with and without coronary endothelial dysfunction.
Specific changes in circulating progenitor cell subsets may represent an early manifestation of atherosclerosis.
These findings highlight the potential role of progenitor cell alterations in the early stages of atherosclerotic disease.