Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 4, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

DNA-programmable multiplexing for scalable, renewable redox protein bio-nanoelectronics.

Gary D Withey1, Jin Ho Kim, Jimmy Xu

  • 1Biomedical Engineering Program, Brown University, 184 Hope Street, Providence, Rhode Island 02912, USA. gary_withey@brown.edu

Bioelectrochemistry (Amsterdam, Netherlands)
|June 27, 2008
PubMed
Summary

A novel DNA linking strategy enables programmable assembly of redox protein nanoelectronic devices. This method allows for versatile, renewable, and site-addressable reconfiguration of enzymes on nanoelectrodes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of distant metastases in salivary gland cancer patients undergoing upfront surgery followed by postoperative radiation therapy: a multicenter analysis.

Japanese journal of clinical oncology·2026
Same author

Core Microbiota Drives Host-Specific Growth Enhancement: Evidence in a Harmful Algal Bloom Causing Dinoflagellate <i>Prorocentrum lima</i>.

Environmental science & technology·2026
Same author

The Use of the Split Jejunal and Colon Patch Within the Oral Cavity: A Systematic Review and Meta-Analysis.

The Journal of craniofacial surgery·2026
Same author

Temporal Patterns and Resolution of Toxicities Following Hypofractionated Salvage Radiotherapy for Biochemical Recurrence of Prostate Cancer After Prostatectomy.

The Prostate·2026
Same author

Metabolic and transcriptional plasticity supports CD8<sup>+</sup> T cell resilience and anti-tumor immunity under nutrient stress.

Immunity·2026
Same author

A Novel <i>ACTB</i> Truncating Variant in a Neonate with ACTB-Related Neurodevelopmental Disorder with Features Overlapping Baraitser-Winter Cerebrofrontofacial Syndrome Diagnosed Using Whole Genome Sequencing: A Case Report.

Annals of clinical and laboratory science·2026

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Electrochemistry

Background:

  • Redox protein nanoelectronic devices are crucial for biosensing and energy applications.
  • Current methods for assembling these devices lack versatility and reconfigurability.
  • Site-specific immobilization of enzymes onto nanomaterials remains a challenge.

Purpose of the Study:

  • To develop a universal, site-addressable DNA linking strategy for programmable assembly of redox protein nanoelectronic devices.
  • To demonstrate the versatility, renewability, and scalability of this DNA-based assembly approach.
  • To enable reconfigurable and renewable transduction of redox protein signals.

Main Methods:

  • A universal DNA linking strategy was developed for conjugating redox proteins to nanomaterials.

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

Related Experiment Videos

Last Updated: Jul 4, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

  • Two model enzymes, glucose oxidase (GOx) and alcohol dehydrogenase (ADH), were tagged with single-stranded DNA (ssDNA).
  • These tagged enzymes were self-assembled onto carbon nanotube (CNT) arrays functionalized with complementary DNA strands for site-specific addressing.

    • Main Results:

    • The DNA linking strategy proved effective for programmable assembly of redox protein nanoelectronic devices.
    • The system demonstrated multiplexed, scalable, and reconfigurable transduction of redox signals.
    • The strategy allows for the reconfiguration and replacement of enzymes, enhancing device renewability.

    Conclusions:

    • The developed DNA linking strategy offers a universal and site-addressable method for constructing advanced redox protein nanoelectronic devices.
    • This approach significantly enhances the versatility, scalability, and renewability of nanoelectronic biosensor systems.
    • The findings pave the way for next-generation, adaptable biosensing and bioelectronic platforms.