Related Experiment Video
Updated: Jul 4, 2026
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Evaluation of normal prostate tissue, chronic prostatitis, and prostate cancer by quantitative perfusion analysis
Tobias Franiel1, Lutz Lüdemann, Birgit Rudolph
1Departments of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany. tobias.franiel@charite.de
Objective:
To quantify independent pharmacokinetic parameters for differentiation of prostate pathology.
Material And Methods:
Twenty-seven patients with biopsy-proven prostate cancer (PSA: 1.4-16.1 ng/mL) underwent magnetic resonance imaging with a new dynamic contrast-enhanced, inversion-prepared dual-contrast gradient echo sequence (T1/T2*-weighted, 1.65 seconds temporal resolution) using a combined endorectal/body phased-array coil at 1.5 Tesla. Perfusion, blood volume, mean transit time, delay, and dispersion were calculated using a sequential 3-compartment model. Twenty-three patients underwent prostatectomy. For histologic correlation a pathologist mapped areas of normal prostate tissue, chronic prostatitis, and prostate cancer (total of 63 areas) on histologic sections corresponding to the magnetic resonance imaging planes.
Results:
Compared with normal prostate tissue, low-grade cancer (Gleason score
Conclusion:
The pharmacokinetic parameters investigated, especially perfusion, allow statistically significant in situ differentiation of normal prostate tissue from cancer and chronic prostatitis and of high-grade cancer from chronic prostatitis.
