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Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

The association between flow-mediated dilation and physical function in older men.

Michael A Welsch¹, Devon A Dobrosielski, Arturo A Arce-Esquivel

¹Louisiana State University, Baton Rouge, LA, USA. mwelsch@lsu.edu

Medicine and Science in Sports and Exercise

|June 27, 2008

Summary

Physical function in older men is linked to vascular health. Higher scores on the Physical Functional Performance (PFP-10) test correlate with better brachial artery flow-mediated dilation (BAFMD), indicating improved vascular function.

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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Area of Science:

Gerontology
Vascular Biology
Physical Medicine

Background:

Independent living in older adults is crucial.
Physical functional performance (PFP-10) is a key indicator of health.
Vascular function, assessed by brachial artery flow-mediated dilation (BAFMD), is vital for cardiovascular health.

Purpose of the Study:

To investigate the relationship between brachial artery flow-mediated dilation (BAFMD) and scores on the Physical Functional Performance (PFP-10) test.
To determine if lower PFP-10 scores are associated with reduced BAFMD in elderly men.

Main Methods:

Sixty-four elderly men (average age 84) from the Louisiana Healthy Aging Study were analyzed.
Participants were categorized into three classes based on PFP-10 scores (<26, 26-57, >57).
BAFMD was measured using high-resolution ultrasonography after forearm occlusion.

Main Results:

A significant positive correlation was found between total PFP-10 scores and BAFMD (r = 0.45, P = 0.0001).
BAFMD levels differed significantly across PFP-10 performance classes (P = 0.001).
The highest functional class (PFP-10 > 57) showed the greatest BAFMD (4.01%), compared to the middle (2.67%) and lowest (1.44%) classes.

Conclusions:

Significant associations exist between BAFMD and physical function measures in elderly men.
Higher physical functional performance is linked to enhanced vascular reactivity.
These findings highlight the interplay between physical function and vascular health in aging men.